Original Articles

  1. Kondo T#, Takayama Y#, Kumagai Y#, Takemura N, Hatakeyama S, Tominaga M, Maruyama K*.

    Bacterial extracellular vesicle ssRNA prevents colorectal cancer progression via Piezo1.

    Cell Rep 45:116737, 2026.

  2. Sakatani H, Konoa M, Hijiya M, Morita Y, Sumitomo T, Inukai T, Nakamura S, Koizumi Y, Maruyama K, Saika S, Murakami M, Hotomi M*.

    Trigeminal TRPV1 regulates pneumococcal nose-to-brain invasion via IL-6/TNF-α signals.

    mBio 16:e0133525, 2025.

  3. Gocho S*, Miyagi Y, Nakayama C, Miyachi Y, Okada S, Maruyama K, Oshima T.

    Comfort distance between patients and pharmacists during medication instruction: A prospective observational study at a cancer chemotherapy center.

    Neuropsychopharmacol Rep 44:698-705, 2024.

  4. Lu YZ, Nayer B, Singh SK, Alshoubaki YK, Yuan E, Park AJ, Maruyama K, Akira S, Martino MM*.

    CGRP sensory neurons promote tissue healing via neutrophils and macrophages.

    Nature 628:604-611, 2024.

  5. Sugisawa E#, Kondo T#, Kumagai Y, Kato H, Takayama Y, Isohashi K, Shimosegawa E, Takemura N, Hayashi Y, Sasaki T, Martino MM, Tominaga M, Maruyama K*.

    Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia.

    Cell Rep 38:110462, 2022.

  6. Maruyama K*, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, Eid MMA, Tanaka H, Martino MM, Takakura N, Takayama Y, Akira S, Vandenbon A, Kumagai Y.

    Zinc finger protein St18 protects septic death by inhibiting VEGF-A from macrophages.

    Cell Rep 32:107906, 2020.

  7. Sugisawa E#, Takayama Y#, Takemura N#, Kondo T#, Hatakeyama S, Kumagai Y, Sunagawa M, Tominaga M, Maruyama K*.

    RNA sensing by gut Piezo1 is essential for systemic serotonin synthesis.

    Cell 182:609-624, 2020.

  8. Julier Z, Karami R, Nayer B, Lu YZ, Park AJ, Maruyama K, Kuhn GA, Muller R, Akira S, Martino MM*.

    Enhancing the regenerative effectiveness of growth factors by local inhibition of interleukin-1 receptor signaling.

    Sci Adv 6: eaba7602, 2020.

  9. Maruyama K*#, Takayama Y#, Sugisawa E, Yamanoi Y, Yokawa T, Kondo T, Ishibashi KI, Sahoo BR, Takemura N, Mori Y, Kanemaru H, Kumagai Y, Martino MM, Yoshioka Y, Nishijo H, Tanaka H, Sasaki A, Ohno N, Iwakura Y, Moriyama Y, Nomura M, Akira S, Tominaga M*.

    The ATP transporter VNUT mediates induction of Dectin-1-triggered Candida nociception.

    iScience 6: 306-318, 2018.

  10. Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, Kuniyoshi K, Tanaka H, Maruyama K, Maeda K, Satoh T, Akira S*.

    Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.

    ProcNatl Acad Sci U S A 114: 7331-7340, 2017.

  11. Sahoo BR, Maruyama K, Edula JR, Tougan T, Lin Y, Lee YH, Horii T, Fujiwara T*.

    Mechanistic and structural basis of bioengineered bovine Cathelicidin-5 with optimized therapeutic activity.

    Sci Rep 7: Article number 44781, 2017.

  12. Maruyama K*, Takayama Y, Kondo T, Ishibashi KI, Sahoo BR, Kanemaru H, Kumagai Y, Martino MM, Tanaka H, Ohno N, Iwakura Y, Takemura N, Tominaga M, Akira S.

    Nociceptors Boost the Resolution of Fungal Osteo-inflammation via the TRP channel-CGRP-Jdp2 axis.

    Cell Rep 19: 2730-2742, 2017.

  13. Lee MSJ, Maruyama K, Fujita Y, Konishi A, Lelliott PM, Itagaki S, Horii T, Lin J, Kahn S, Kuroda E, Akira S, Ishii KJ, Coban C*.

    Plasmodium products persist in the bone marrow and promote chronic bone loss.

    Sci Immunol 2: piieaam8093, 2017. (Cover Picture)

  14. Maruyama K*, Kawasaki T, Hamaguchi M, Hashimoto M, Furu M, Ito H, Fujii T, Takemura N, Karuppuchamy T, Kondo T, Kawasaki T, Fukasaka M, Misawa T, Saitoh T, Suzuki Y, Martino MM, Kumagai Y, Akira S*.

    Bone-protective Functions of Netrin 1 Protein.

    J Biol Chem 291: 23854-23868, 2016. (Cover Picture)

  15. Martino MM*, Maruyama K, Stanger S, Satoh T, Takeuchi O, Muller R, Akira S*.

    Inhibition of IL-1R1/MyD88 signaling promotes mesenchymal stem cell-driven tissue
    regeneration.

    Nat Commun 7: Article number 11051, 2016.

  16. Kuroda Y, Maruyama K, Fujii H, Sugawara I, Ko SBH, Yasuda H, Matsui H, Matsuo K*.

    Osteoprotegerin Regulates Pancreatic β-Cell Homeostasis upon Microbial Invasion.

    PLoS One 11: e0146544, 2016.

  17. Maruyama K*, Fukasaka M, Uematsu S, Takeuchi O, Kondo T, Saitoh T, Martino MM, Akira S*.
    5-azacytidine-induced protein 2 (AZI2) regulates bone mass by fine tuning osteoclast survival.

    J Biol Chem 290:9377-9386, 2015. (Cover Picture)

  18. Maruyama K, Uematsu S, Kondo T, Martino MM, Kawasaki T, Akira S*.

    Strawberry notch homologue 2 regulates osteoclast fusion by enhancing the expression of DC-STAMP.

    J Exp Med 210: 1947-1960, 2013. (Cover Picture)

  19. Fukasaka M, Ori D, Kawagoe T, Uematsu S, Maruyama K, Okazaki T, Kozaki T, Imamura T, Tartey S, Mino T, Satoh T, Akira S, Takeuchi O*.

    Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.

    J Immunol 190: 5702-5711, 2013.

  20. Kondo T, Kobayashi J, Saitoh T, Maruyama K, Ishii KJ, Barber GN, Komatsu K, Akira S*, Kawai T*.

    DNA damage sensor MRE11 recognizes cytosolic double-stranded DNA and induces type I interferon by regulating STING trafficking.

    Proc Natl Acad Sci U S A 110: 2969-2974, 2013.

  21. Maruyama K, Fukasaka M, Vandenbon A, Saitoh T, Kawasaki T, Kondo T, Yokoyama KK, Kidoya H, Takakura N, Standley D, Takeuchi O, Akira S*.

    The transcription factor Jun dimerization protein 2 controls bone homeostasis and antibacterial immunity by regulating osteoclast and neutrophil differentiation.　

    Immunity 37:1024-1036, 2012.

  22. Maruyama K, Kawagoe T, Kondo T, Akira S*, Takeuchi O*.

    TRAF family member-associated NF-κB activator (TANK) is a negative regulator of osteoclastogenesis and bone formation.

    J Biol Chem 287: 29114-29124, 2012.

  23. Yamaguchi T, Takada Y, Maruyama K, Shimoda K, Arai Y, Nango N, Kosaki N, Takaishi H, Toyama Y, Matsuo K*.

    Fra-1/AP-1 Impairs Inflammatory Responses and Chondrogenesis in Fracture Healing.

    J Bone Miner Res 24: 2056-2060, 2009.

  24. MaruyamaK, Sano G, Ray N, Takada Y, Matsuo K*.

    c-Fos-deficient mice are susceptible to Salmonella enterica Serovar Typhimurium infection.

    Infect Immun 75: 1520-1523, 2007.

  25. Sano G, Takada Y, Goto S, Maruyama K, Shindo Y, Oka K, Matsui H, Matsuo K*.

    Flagella Facilitate Escape of Salmonella from Oncotic Macrophages.

    J Bacteriol 189: 8224-8232, 2007.

  26. Ray N, Kuwahara M, Takada Y, Maruyama K, Kawaguchi T, Tsubone H, Ishikawa H, Matsuo K*.

    c-Fos suppresses systemic inflammatory response to endotoxin.

    Int Immunol 18: 671-677, 2006.

  27. MaruyamaK, Takada Y, Ray N, Kishimoto Y, Penninger JM, Yasuda H, Matsuo K*.

    Receptor Activator of NF-κB Ligand and Osteoprotegerin Regulate Proinflammatory Cytokine Production in Mice.

    J Immunol 177 : 3799-3805, 2006.

  28. MaruyamaK, Sano G, Matsuo K*.

    Murine osteoblasts respond to LPS and IFN-γ similarly to macrophages.

    J Bone Miner Metab 24:454-460, 2006.

    *corresponding author, #equally contribution

Reviews

  1. Miyamoto S, Takayama Y*, Kondo T, Maruyama K*.

    Senso-immunology: the hidden relationship between sensory system and immune system.

    J Bone Miner Metab 42:413-420, 2024.

  2. Fujikawa M, Ueda M, Maruyama K*.

    Role of Kynurenine and its Derivatives in Neuroimmune System.

    Int J Mol Sci 25: 7144, 2024.

  3. Kondo T, Okada Y, Saika S, Yamaguchi N, Hatakeyama S, Maruyama K*.

    Neuroimmune modulation by tryptophan derivatives in neurological and inflammatory disorders.

    Eur J Cell Biol 103:151418, 2024.

  4. Maruyama K*.

    Senso-immunology : the emerging connection between pain and immunity.

    Keio J Med 72:77-87, 2023.

  5. Miyamoto S, Kondo T, Maruyama K*.

    Senso-immunology : the past, present, and future.

    J Biochem 174:305-315, 2023.

  6. Okumo T*, Takayama Y*, Maruyama K*, Kato M, Sunagawa M*.

    Senso-immunologic prospects for complex regional pain syndrome treatment.

    Front Immunol 12:786511, 2022.

  7. Maruyama K*.

    Senso-immunology: crosstalk between nociceptive and immune systems.

    FEBS J doi: 10.1111/febs.15846. 2021.

  8. Takayama Y*, Derouiche S*, Maruyama K*, Tominaga M*.

    Emerging Perspectives on Pain Management by Modulation of TRP Channels and ANO1.

    Int J Mol Sci 20:3411, 2019.

  9. Larouche J, Sheoran S, Maruyama K, Martino MM*.

    Immune Regulation of Skin Wound Healing: Mechanisms and Novel Therapeutic Targets.

    Adv Wound Care 7:209-231, 2018.

  10. Maruyama K*, Takemura N, Martino MM, Kondo T, Akira S.

    Netrins as Prophylactic Targets of Skeletal diseases: A Double-Edged Sword?

    Pharmacol Res 122: 46-52, 2017.

  11. Martino MM, Briquez PS, Maruyama K, Hubbell JA*.

    Extracellular matrix-inspired growth factor delivery systems for bone regeneration.

    Adv Drug Deliv Rev 94: 41-52, 2015. 　

  12. Maruyama K*, Akira S*.

    Emerging molecules in the interface between skeletal system and innate immunity.

    Pharmacol Res 99: 223-228, 2015.

    *corresponding author

Misc

  1. 上田昌史、丸山健太

    感覚免疫学

    口腔・咽頭科 38:245-255, 2025.

  2. 丸山健太

    骨髄移植ドナーはHotな食事を　

    実験医学 39:1239-1240, 2021.

  3. 丸山健太　

    腸内リボ核酸による骨粗鬆症の病態修飾に関する研究　

    Aging & Health 30:39-41, 2021.

  4. 丸山健太　

    感覚免疫学　

    ブレインサイエンス・レビュー2021 173-193, 2021.

  5. 丸山健太　

    腸内細菌RNAのセロトニン誘導による腸と骨の恒常性の制御　

    BIOSCIENCE & INDUSTRY 79:34-35, 2021.

  6. 丸山健太　

    腸のPiezo1はセロトニン産生を介して腸と骨の恒常性を調節する　

    実験医学 38:3256-3258, 2020.

  7. 丸山健太　

    痛みは如何にして感知され、どのような意味を持つのか？～末梢性疼痛のしられざる発生機構とその生体調節機能～　

    実験医学 38:388-395, 2020.

  8. 丸山健太

    感覚免疫学の視点からみた真菌感染不快情動のバイオロジー～Dectin1シグナルを介して制御される痛みと骨炎症～　

    THE BONE 33: 29-37, 2019.

  9. 丸山健太

    接触性皮膚炎の病態はわさびとからしの受容体で説明できる　

    実験医学 36:3269-3270, 2018.

  10. 丸山健太

    無痛マウスは黄色ブドウ球菌性肺炎で死なない？　

    実験医学 36: 3269-3270, 2018.

  11. 丸山健太

    Type2サイトカインによる感覚神経の直接刺激が痒みを増悪させる

    実験医学 35: 3245-3246, 2017.

  12. 丸山健太、審良静男　

    Jdp2は破骨細胞および好中球の正常な分化に必須である

    新着論文レビュー DOI 10.7875/first.author.2012.155, 2012.

  13. 丸山健太、審良静男

    破血症の病態整理とPattern-Recognition Receptors  

    ICUとCCU  35: 361-366, 2011.

  14. 松尾光一、丸山健太、高田康成

    転写因子AP-1と骨‘自然’免疫

    ホルモンと臨床 54: 757-762, 2006.

  15. 丸山健太、松尾光一

    LPS刺激応答における転写因子AP-1の機能

    エンドトキシン研究9 137-141, 2006.

Introductory Articles

  1. Wong W.

    ssRNA stimulates Piezo1 and serotonin synthesis.

    Science Signaling “Editor’s choice” 13: eabe6325

  2. Beech DJ, Lichtenstein L.

    RNA and the PIEZO force sensor.

    Cell Res “Research Highlight” 0:1-2, 2020.

  3. Matute JD, Duan J, Blumberg RS.

    Microbial RNAs Pressure Piezo1 to Respond.

    Cell “Previews” 182:542-544, 2020.

  4. Buchhagen DL.

    RANK(L)ing Endotoxin Shock.

    J Immunol “In this issue” 177:3505-3506, 2006.

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